Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor

PSD-95 REGULATES SEROTONIN RECEPTOR FUNCTION IN VIVO by ATHEIR

We hereby approve the dissertation of Atheir Ibrahim Abbas

Serotonin receptor 3A controls interneuron migration into the neocortex

Neuronal excitability has been shown to control the migration and cortical integration of reelin-expressing cortical interneurons (INs) arising from the caudal ganglionic eminence (CGE), supporting the possibility that neurotransmitters could regulate this process. Here we show that the ionotropic serotonin receptor 3A (5-HT(3A)R) is specifically expressed in CGE-derived migrating interneurons ...

Establishing Human Lacrimal Gland Cultures with Secretory Function

PURPOSE Dry eye syndrome is a multifactorial chronic disabling disease mainly caused by the functional disruptions in the lacrimal gland. The treatment involves palliation like ocular surface lubrication and rehydration. Cell therapy involving replacement of the gland is a promising alternative for providing long-term relief to patients. This study aimed to establish functionally competent lacr...

Serotonin receptor 3A polymorphism C178T is associated with severe dyspepsia

Serotonin receptor 3A expression in normal and neoplastic B cells.

Chromosome 11q21-qter is a very gene-rich region and is often targeted by genomic aberrations in a variety of human cancers, including B cell lymphoid neoplasms. In order to identify genes which could be deregulated in diffuse large B cell lymphomas (DLBCL), we analyzed the expression levels of genes mapped on chromosome 11q21-qter across a series of publicly available DLBCL expression data set...